Meiler Lab Computational Chemical and Structural Biology |
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Pranav Kodali
Former Undergraduate Student
Undergraduate
Pranav.kodali [ at ] vanderbilt.edu
The Vanderbilt Program for Next Generation Vaccines aims to integrate big data and structural biology into the design pipeline for new vaccines. One crucial step in this process is the modeling of the 3D structures of antibodies from their amino acid sequences. Comparative modeling of antibodies is usually applied using only one structure as a template for the entire antibody (single template modelling) or one structure as a template for each CDR and the entire framework regions (RosettaAntibody modelling). However, the use of multiple templates (multi-template modelling) has been shown to improve the accuracy of modeling for other types of proteins. I am working on a protocol that utilizes multitemplate modeling in RosettaCM to improve the modeling of antibodies.
Publication Link:
https://scholar.google.com/citations?hl=en&user=62K2DsMAAAAJ
Supervised by: Clara T. Schoeder
Center for Structural Biology
465 21st Ave South, BIOSCI/MRBIII
Vanderbilt University, Nashville, TN