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Meiler Lab Computational Chemical and Structural Biology |
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Group Members
Brian Bender
Former Graduate Student
B.A. Biochemistry
brian.j.bender [ at ] vanderbilt.edu
Research Interests:
I use computational modeling and biophysical techniques to understand how proteins interact with their binding partners such as small molecules, peptides, or large proteins. The Meiler Lab actively develops the Rosetta software for protein structure prediction. I complement this software with biophysical techniques such as X-ray crystallography, nuclear magnetic resonance (NMR), and electron paramagnetic resonance (EPR). I have a particular focus on G-protein coupled receptors (GPCRs). I am interested in how ligand binding induces a conformational change in the receptor to lead to activation and signaling through cellular binding proteins such as heterotrimeric G-protein and arrestin. Additionally I design protein-ligand interfaces to enhance binding to non-native ligands.
- Research Projects
- Publications
Protocols for Molecular Modeling with Rosetta3 and RosettaScripts (2016) Biochemistry
Schmidt P;Bender BJ, Kaiser A, Gulati K, Scheidt HA, Hamm HE, Meiler J, Beck-Sickinger AG, Huster D.
Improved in Vitro Folding of the Y2 G Protein-Coupled Receptor into Bicelles. (2018) Front Mol Biosci.
Moretti R;Bender BJ, Allison B, Meiler J
Rosetta and the Design of Ligand Binding Sites. (2016) Methods Mol Biol.
Yang Z;Han S, Keller M, Kaiser A, Bender BJ, Bosse M, Burkert K, Kögler LM, Wifling D, Bernhardt G, Plank N, Littmann T, Schmidt P, Yi C, Li B, Ye S, Zhang R, Xu B, Larhammar D, Stevens RC, Huster D, Meiler J, Zhao Q, Beck-Sickinger AG, Buschauer A, Wu B
Structural basis of ligand binding modes at the neuropeptide Y Y1 receptor. (2018) Nature
Sanchez-Soto M;Casado-Anguera V, Yano H, Bender BJ, Cai NS, Moreno E, Canela EI, Cortes A, Meiler J, Casado V, Ferre S
alpha2A- and alpha2C-Adrenoceptors as Potential Targets for Dopamine and Dopamine Receptor Ligands. (2018) Mol Neurobiol.