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Meiler Lab Computational Chemical and Structural Biology |
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Group Members
Amanda Duran
Former Graduate Student
N/A
amanda.m.duran [ at ] vanderbilt.edu
Research Interests:
Many membrane proteins exhibit structural pseudo-symmetry. My current research project aims to engineer a membrane protein that is perfectly symmetric in sequence as well as structure. Small, stable proteins are an ideal unit towards the construction of large, stable protein complexes. Rosetta Membrane, Design, and Symmetry are being combined to computationally engineer a symmetric membrane protein. I also have interests in the wet lab as I will clone, express, and purify proteins and use CD, X-ray crystallography, and NMR Spectroscopy to experimentally verify proteins.
- Research Projects
- Publications
Amanda Duran;Jens Meiler
Inverted Topologies in Membrane Proteins: A Mini-Review (2013) Computational and Structural Biotechnology Journal
Brett M. Kroncke;Amanda M. Duran, Jeffrey L. Mendenhall, Jens Meiler, Jeffrey D. Blume, Charles R. Sanders
Documentation of an Imperative To Improve Methods for Predicting Membrane Protein Stability (2016) American Chemical Society
Duran AM;Meiler J
Computational design of membrane proteins using RosettaMembrane. (2018) Protein Sci
Hui Huang;G Kuenze, JA. Smith, KC. Taylor, AM. Duran, A Hadziselimovic, Jens Meiler, Carlos G. Vanoye, Alfred L. George Jr, C R. Sanders
Mechanisms of KCNQ1 channel dysfunction in long QT syndrome involving voltage sensor domain mutations (2018) Science advances
Xia Y;Ledwitch K, Kuenze G, Duran A, Li J, Sanders CR, Manning C, Meiler J
A unified structural model of the mammalian translocator protein (TSPO) (2019) J Biomol NMR
Brian J. Bender;Alberto Cisneros, Amanda M. Duran, Jessica A. Finn, Darwin Fu, Alyssa D. Lokits, Benjamin K. Mueller, Amandeep K. Sangha, Marion F. Sauer, Alexander M. Sevy, Gregory Sliwoski, Jonathan H. Sheehan, Frank DiMaio, Jens Meiler, and Rocco Moretti
Protocols for Molecular Modeling with Rosetta3 and RosettaScripts (2016) Biochemistry
Inverted Topologies in Membrane Proteins: A Mini-Review (2013) Computational and Structural Biotechnology Journal
Brett M. Kroncke;Amanda M. Duran, Jeffrey L. Mendenhall, Jens Meiler, Jeffrey D. Blume, Charles R. Sanders
Documentation of an Imperative To Improve Methods for Predicting Membrane Protein Stability (2016) American Chemical Society
Duran AM;Meiler J
Computational design of membrane proteins using RosettaMembrane. (2018) Protein Sci
Hui Huang;G Kuenze, JA. Smith, KC. Taylor, AM. Duran, A Hadziselimovic, Jens Meiler, Carlos G. Vanoye, Alfred L. George Jr, C R. Sanders
Mechanisms of KCNQ1 channel dysfunction in long QT syndrome involving voltage sensor domain mutations (2018) Science advances
Xia Y;Ledwitch K, Kuenze G, Duran A, Li J, Sanders CR, Manning C, Meiler J
A unified structural model of the mammalian translocator protein (TSPO) (2019) J Biomol NMR
Brian J. Bender;Alberto Cisneros, Amanda M. Duran, Jessica A. Finn, Darwin Fu, Alyssa D. Lokits, Benjamin K. Mueller, Amandeep K. Sangha, Marion F. Sauer, Alexander M. Sevy, Gregory Sliwoski, Jonathan H. Sheehan, Frank DiMaio, Jens Meiler, and Rocco Moretti
Protocols for Molecular Modeling with Rosetta3 and RosettaScripts (2016) Biochemistry