Group Members

Younghee Park

Current Post-Doctoral Fellow

PhD in Biochemistry, University of Georgia, USA
younghee.park [ at ] vanderbilt.edu
Vanderbilt University - MBRIII 5140 Office Suite

Research Interests:

• Membrane protein
• Structural biology
• Protein-protein interaction
• NMR
• MD simulation

My research interest is the study of membrane protein structures associated with human diseases. Particularly, I have utilized NMR spectroscopy to determine protein structures at an atomic level. My postdoctoral research will be focusing on developing a method in tagging proteins with metals or nitroxide spin-labels in order to obtain long-range distance and using this as a restraint in Rosetta to refine protein structures.
I’m also interested in working to study protein-protein interactions on the transmembrane complexes DAP12 and TREM2. Mutations in DAP12 and TREM2 are associated with neurodegenerative diseases, such as Alzheimer’s disease.  Using BCL docking and molecular dynamics simulations, I would like to gain insight into the atomic details of the key residues within the protein-protein interface and the molecular mechanism of signal activation.