Meiler Lab Computational Chemical and Structural Biology |
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Katherine Larochelle
Current Graduate Student
BS in Biochemistry, University of Maine, USA
katherine.e.larochelle [ at ] vanderbilt.edu
Vanderbilt University - MBRIII 5140 Office Suite
My research in the Meiler Lab involves expressing and purifying membrane proteins from E. coli for a wide variety of applications. These applications include paramagnetic NMR, electron paramagnetic resonance (EPR), and small-angle neutron scattering (SANS). For NMR and EPR, I site-specifically encode a noncanonical amino acid for site-directed paramagnetic spin labeling, which gives rise to a rich source of structural information for computational modeling. Additionally, I work on deuteration protocols for expressing, purifying and circularizing cNW9 nanodiscs for membrane protein reconstitution and investigations by SANS. My long-term goal is to pursue graduate studies in structural biology and protein biochemistry.