Meiler Lab Computational Chemical and Structural Biology |
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Laura Friggeri
Current Post-Doctoral Fellow
PhD in Pharmaceutical Sciences, Sapienza University of Rome, Italy
laura.friggeri [ at ] vanderbilt.edu
Vanderbilt University - MBRIII 5140 Office Suite
Collaboration with Prof. Craig W. Lindsley
Project Description:
I am working to develop novel chemotypes targeting allosteric binding pockets of GPCRs, particularly the class C metabotropic glutamate receptors (mGluRs) by combining computational methods such as structure-based computer aided drug discovery (SB-CADD), ligand-based computer aided drug discovery (LB-CADD), and chemical synthesis. Integration of structural models with small molecule structure-activity relationship data can help us identify novel scaffolds with a focus on drug-like properties (solubility, absorption, metabolism, etc.) to be applied to new biological targets.
Publication Link:
https://www.ncbi.nlm.nih.gov/myncbi/1tyFvkNlcUCIeY/bibliography/public/